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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Nat Genet. 2013 Oct 20;45(12):1494–1498. doi: 10.1038/ng.2803

Figure 3. GATA3 SNP rs3824662 risk allele frequency and the constellation of multiple “Ph-like ALL related” genomic lesions (CRLF2 lesion, JAK mutation, and IKZF1 deletion).

Figure 3

Patients in COG AALL0232, COG P9906, and COG P9905 cohorts were grouped as triple positive, double positive, single positive and triple negative based on their status for somatic CRLF2 lesion, JAK mutation, and IKZF1 deletion. Risk (A) allele frequency at rs3824662 was highest in patients carrying all three lesions and lowest in patients carrying no lesions at these three genes, with a positive correlation between A allele frequency and the cumulative number of lesions in three cohorts (P=6.9×10−5, P=0.0005 and P=7.6×10−5, respectively), as determined by the ordinal regression test adjusting genetic ancestry.