Table 1. Summary, in Chronological Order, of Studies on Aminoglycoside Pharmacokinetics and Dose Adjustment in Obesity .
| Author, year | Antibiotic studied | Main findings |
|---|---|---|
| Schwartz et al, 1978 [1] | Gentamicin, tobramycin | Vd in obese subjects closely approximates Vd in normal subjects when using the formula: ABW = IBW + 0.4 × (TBW - IBW) |
| Blouin et al, 1979 [2] | Tobramycin | Tobramycin loading dose based on ABW = IBW + 0.58 × (TBW - IBW) |
| Korsager, 1980 [4] | Gentamicin | Gentamicin uptake in adipose tissue = 43.7% of uptake in total body mass of normal-weight patients |
| Bauer et al, 1980 [3] | Amikacin | Amikacin loading dose based on ABW = IBW + 0.38 × (TBW - IBW) |
| Bauer et al, 1983 [5] | Gentamicin, tobramycin, amikacin | Loading dose based on ABW = IBW + 0.4 × (TBW - IBW) |
| Leader et al, 1994 [11] | Gentamicin | Initial dose based on calculation of ClCr by Cockroft equation with IBW + 0.4 × (TBW - IBW) |
| Traynor et al, 1995 [8] | Tobramycin | The TBW/IBW ratio predicts Vd. For patients with TBW/IBW ratio ≥ 1.25, doses based on ABW = IBW + 0.43 × (TBW - IBW) |
| Wurtz et al, 1997 [10] | Aminoglycosides | DWCF = 0.4, therefore ABW = IBW + 0.4 × (TBW - IBW) |
| Pai et al, 2007 [12] | Aminoglycosides | Dosing of aminoglycosides should be based on ABW. |
ABW: adjusted body weight; ClCr: creatinine clearance; DWCF: dosing weight correction factor; IBW: ideal body weight; TBW: total body weight; Vd: volume of distribution.