Table 1. Patient and disease characteristics.
Patients were excluded from analysis if they were withdrawn during the study duration for any reason, lack a baseline sample, or lack a sample following cycle 1 initiation.
| Variable | Descriptive Statistics (Total n=22) |
| Gender Male Female |
14 (64%) 8 (36%) |
| Age Mean(SD) Median (Range) |
63.5 (15.3) 68.5 (27 – 88) |
| Primary Location Rectum Colon |
(n= 2 missing) 8 (40%) 12 (60%) |
| Primary Histology Adenocarcinoma With signet ring cell features With mucinous features |
(n= 2 missing) 16 (80%) 1 (5%) 3 (15%) |
| Primary Differentiation Well or moderate Poor or differentiated |
(n= 4 missing) 14 (78%) 4 (22%) |
| Liver Metastasis Yes No |
(n= 2 missing) 11 (55%) 9 (45%) |
| Lung Metastasis Yes No |
(n= 2 missing) 10 (50%) 10 (50%) |
| T 2 3 4 |
(n= 10 missing) 1 (8%) 5 (42%) 6 (50%) |
| N 0 1 2 |
(n= 10 missing) 1 (8%) 1 (8%) 10 (83%) |
| Variable | Descriptive Statistics (Total n=22) |
| Lymphatic Invasion Yes No |
(n= 11 missing) 7 (64%) 4 (36%) |
| Venous Invasion Yes No |
(n= 12 missing) 5 (50%) 5 (50%) |
| Perineural Invasion Yes No |
(n= 11 missing) 4 (36%) 7 (64%) |
| KRAS WT G12A G12V |
(n= 5 missing) 15 (88%) 1 (6%) 1 (6%) |
| BRAF WT V600E |
(n= 6 missing) 14 (88%) 2 (12%) |
| EGFR Expression Mean(SD) Median (Range) |
(n= 10 missing) 2.9 (1.8) 2.1 (1.1 – 6.5) |
| ERCC1 Expression Mean(SD) Median (Range) |
(n= 10 missing) 1.2 (0.7) 1.1 (0.4 – 3.1) |
| TS Expression Mean(SD) Median (Range) |
(n= 10 missing) 3.6 (1.9) 3.6 (1.5 – 7.0) |
| CEA Mean(SD) Median (Range) |
(n= 2 missing) 294.6 (1104.4) 7.6 (1.6 – 4967.7) |
| Tumor-Liver volume ratio Mean(SD) Median (Range) |
(n=13 missing) 0.2 (0.3) 0 (0 – 0.7) |