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. 2014 Mar 28;5(8):2016–2029. doi: 10.18632/oncotarget.1875

Figure 4. Signaling activators induce transcription of EMT-TFs which in turn regulate histone modifications on target genes.

Figure 4

Upon inducing signal, activating histone modifications on the genes of EMT-TFs promote transcription. EMT-TFs then interact with epigenetic regulators to mark the target genes for activation or repression.