Figure 2. Pair-wise Combinations of MDM2 Inhibitors with PI3K or MAPK Pathway Inhibitors Exhibit Broad and Robust Synergy Across Cell Lines.

Heat-map representation of synergy scores from MDM2 inhibitor combinations with (A) PI3K or (B) MAPK pathway inhibitors across a panel of 40 cell lines. Cell viability was assessed by ATP quantification following 72 hours of inhibitor treatment. Synergy scores were calculated using the Loewe additivity model. Darker red indicates greater synergy. See also Tables S2-S4.