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. 2014 Apr 23;5(8):2030–2043. doi: 10.18632/oncotarget.1918

Figure 7. Triple Combinations of MDM2, PI3K, and MEK Inhibitors Produces Greater Reductions in Cell Viability than Two-way Combinations of these Agents.

Figure 7

(A-C) Growth inhibition curves in the RKO cell line for triple combinations of MDM2 inhibitor (AMG 232), MEK inhibitor (PD0325901), and PI3K inhibitor (AMG 511), as well as all 3 cognate double combinations. (D) Representative isobologram showing the concentrations of MDM2 inhibitor (AMG 232), MEK inhibitor (PD0325901), and PI3K inhibitor (AMG 511) that together confer 150% growth inhibition in the RKO cell line. Values on each contour indicate the concentration of MDM2 inhibitor. The molar ratios shown in A-C have been mapped onto this isobologram as colored circles. See also Table S5.