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. 2014 Apr 8;5(8):2198–2207. doi: 10.18632/oncotarget.1889

Figure 2. Mutation analysis of β-catenin gene.

Figure 2

A molecular alteration in exon 3 of the β-catenin gene was observed in 2 non-secreting adrenocortical adenomas. A. β-catenin immunostaining showed strong nuclear accumulation (×400). Nucleotide sequencing of exon 3 of β-catenin showed a T→G transition (L46P) in case 1. B. A small subset of tumor cells showed strong nuclear accumulation of β-catenin (×400). Nucleotide sequencing of exon 3 of β-catenin showed a C→G transition (P44A) and T→C transition (S45P) in case 2.