Table 2. Univariate and multivariate Cox regression analyses ANRIL for DFS or OS of patients in study cohort (n = 120).

Variables	DFS			OS
	HR	95% CI	p value	HR	95% CI	p value
Univariate analysis					.
Age(<50years vs. >50years)	1.271	0.783-2.062	0.318	1.262	0.784-2.032	0.339
Gender(male vs. female)	0.902	0.706-1.154	0.414	0.897	0.704-1.143	0.379
tumor size( >5cm vs. <5cm )	1.268	0.997-1.614	0.053	1.394	1.098-1.768	0.006*
Histologic differentiation(Well+ Moder ately vs. Poorly+ Undifferentiated)	1.241	0.767-2.008	0.379	1.304	0.811-2.097	0.273
Invasion depth(T1+T2 vs.T3+T4)	1.383	0.597-3.204	0.450	1.548	0.669-3.581	0.307
TNM stage (III + IV vs. I+II)	2.116	1.301-3.443	0.003*	2.077	1.287-3.351	0.003*
Lymphatic metastasis(No vs. Yes)	1.533	0.933-2.518	0.092	1.60	0.981-2.607	0.06
Distant metastasis(No vs. Yes)	0.499	0.335-0.744	0.001*	0.544	0.375-0.790	0.001*
Expression of ANRIL (High vs. Low)	1.836	1.134-2.974	0.013*	2.047	1.272-3.293	0.003*
Multivariate analysis
TNM stage (III + IV vs. I+II)	1.994	1.200-3.316	0.008*	1.889	1.142-3.123	0.013*
tumor size( >5cm vs. <5cm )	-	-	-	1.230	0.957-1.581	0.106
Distant metastasis(No vs. Yes)	0.436	0.287-0.662	<0.001*	0.471	0.317-0.699	<0.001*
Expression of ANRIL (High vs. Low)	1.717	1.036-2.844	0.036*	1.743	1.036-2.933	0.036*