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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Neurobiol Learn Mem. 2014 Mar 22;111:65–70. doi: 10.1016/j.nlm.2014.03.006

Figure 3.

Figure 3

Neuroimaging results from the two psychophysiological interaction (PPI) analyses seeded in the locus coeruleus (LC). Increased positive functional connectivity between the LC and left anterior insula (AI) predicted successful memory encoding of pictures from negative feedback trials (left panel). This successful memory-related pattern of LC connectivity was not observed in positive feedback trials. Positive and negative refer to the valence of the action outcome, i.e., “Hit!” or “Miss!” reaction time feedback, respectively. Increased positive functional connectivity between the LC and left dorsolateral prefrontal cortex (DLPFC) predicted successful memory encoding of pictures from low versus high response certainty trials (i.e., reaction times that were closest to versus furthest away from the dynamic response deadline on a given trial). R = remembered; F = forgotten; **p < .01.