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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Jun 26;272(2):299–305. doi: 10.1016/j.taap.2013.06.016

Figure 6. Activation of JAK2/STAT3 signaling pathway in livers of WT, FXR−/−, SHPTg, and FXR−/−/SHPTg mice at 3-, 6-, 12-, and 18-month old.

Figure 6

(A) Q-PCR analysis of mRNA expression levels of STAT3 downstream target genes, c-Myc, p21, Survivin, and Socs3. (B) Serum IL-6 levels in WT, SHPTg and FXR−/− mice at 3-, 6-, 12- and 18-month old; liver IL-6 protein levels in WT and FXR−/− mice at 3-month old. (C) Q-PCR analysis of mRNA expression levels of IL-1β and IL-6 in livers of each genotype at 3-, 6-, 12- and 18-month old. An asterisk indicates P < 0.05 and double asterisks mean P < 0.01 between WT and FXR−/− or FXR−/−/SHPTg mice.