Table 2.

Summarized results of pathology for 18-month old male mice

Groups	Rate of HCC or dysplasia (tumor early stage)	Rate of inflammation (portal)	Rate of inflammation (parenchymal)	Rate of bile ductular proliferation	Rate of necrosis
Wild Type (n=6)	N/A	N/A	N/A	N/A	N/A
FXR Knockout (n=10)	HCC (5/10), high grade dysplasia (5/10)	portal inflammation (6/10): mild (2/10), moderate (1/10), or marked (3/10)	parenchymal inflammaiton (3/10): mild (1/10) or marked (2/10)	2/10	3/10
SHP Transgenic (n=8)	N/A	N/A	N/A	N/A	N/A
FXR Knockout/SHP Transgenic (n=9)	HCC (5/9), high grade dysplasia (1/9), low grade dysplasia (3/9)	portal inflammation (4/9): mild (2/9), moderate (1/9), or marked (1/9)	N/A	1/9	1/9