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Steady-state pharmacokinetic parameters of nifedipine and its oxidized metabolite during pregnancy
| Parameter | Nifedipine | Oxidized Nifedipine |
|---|---|---|
| Cmax (μg/L) | 165±112 (40.6 – 397) | 89.9±80.9 (14.4 – 236) |
| Cave (μg/L) | 41.2±31.0 (12.2–119) | 20.4±15.0 (4.48 – 56.1) |
| kel (h−1) | 0.55±0.20 (0.10 – 0.87) | 0.59±0.34 (0.15 – 1.3) |
| t1/2 (h) | 1.68±1.56 (0.79 – 6.91) | 1.67±1.19 (0.54 – 4.7) |
| CL/F (L/h) | 128±80.4 (39.1–274.8) | |
| Vd/F(L) | 295±262 (60.6–832) |
Data are presented as mean ± standard deviation (range).
