Table 1. Structure activity relationship of different Sd-133 analogues, celecoxib and DMC.

Various substituent (R1 and R2) are shown along with growth inhibition EC50s for three cadherin-11 positive cell lines. NA, Non-applicable: compounds with no significant growth inhibition in MDA-MB-231 cells (EC50 higher than 10 μM shown in red) were omitted for further analysis in other cell lines

Structure
Compound	Systematic (IUPAC) Name	R1	R2	EC50 (MDA-231)	EC50 (BT549)	EC50 (HS578-t)
Sd133-0001A	3-(4-methoxyphenyl)-2-phenyl-pyridin-1-ium chloride	OCH3	H	1.27E-06	1.57E-06	1.95E-06
Sd133-0002A	3-(4-fluorophenyl)-2-phenyl-pyridin-1-ium chloride	F	H	>10E-06	NA	NA
Sd133-0003A	4-(2-phenylpyridin-1-ium-3-yl)phenol chloride [The hydrochloride salt of SD-CAD11-133]	OH	H	4.53E-06	2.25E-06	1.47E-06
Sd133-0004A	3-(4-fluorophenyl)-2-(4-methoxyphenyl)pyridin-1-ium chloride	F	OCH3	>10E-06	NA	NA
Sd133-0005A	2,3-bis(4-methoxyphenyl)pyridin-1-ium chloride	OCH3	OCH3	>10E-06	NA	NA
Sd133-0008A	2-(4-methoxyphenyl)-3-phenyl-pyridin-1-ium chloride	H	OCH3	>10E-06	NA	NA
Structure
Compound	Systematic (IUPAC) Name	R1	R2	EC50 (MDA-231)	EC50 (BT549)	EC50 (HS578-t)
Sd-133	4-(2-phenyl-3-pyridyl)phenol	OH	H	3.32E-06	3.07E-06	2.77E-06
Sd133-0006	4-(3-phenyl-2-pyridyl)phenol	H	OH	>10E-06	NA	NA
Sd133-0007	4-[3-(4-methoxyphenyl)-2-pyridyl]phenol	OCH3	OH	>10E-06	NA	NA
Structure
Compound	Systematic (IUPAC) Name	R1	R2	EC50 (MDA-231)	EC50 (BT549)	EC50 (HS578-t)
SD133-0009A	3-bromo-2-phenyl-pyridin-1-ium chloride	Br	H	>10E-06	NA	NA
SD133-0010A	3-bromo-2-(4-methoxyphenyl)pyridin-1-ium chloride	Br	OCH3	>10E-06	NA	NA
Structure
Compound	Systematic (IUPAC) Name	EC50 (MDA-231)			EC50 (BT549)	EC50 (HS578-t)
Celecoxib	4-[5-(4-methylphenyl)-3-(trifluoromethyl) pyrazol-1-yl]benzenesulfonamide	1.95E-06			4.07E-06	1.27E-06
Structure
Compound	Systematic (IUPAC) Name	EC50 (MDA-231)			EC50 (BT549)	EC50 (HS578-t)
Dimethylcelecoxib	4-[5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide	2.25E-06			4.43E-06	1.42E-06