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. 2014 Mar 4;5(6):1646–1656. doi: 10.18632/oncotarget.1802

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Copyright: © 2014 Cao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Sequential ChIP analysis in 22Rv1 cells with an AR-V7 antibody followed by an AR-FL antibody showing co-occupancy of the PSA, but not UBE2C, promoter by AR-V7 and AR-FL. Enzalutamide (Enz), 10 μM. DHT, 1 nM. B. AR-V7 ChIP analysis in 22Rv1 cells showing AR-V7 binding to the UBE2C promoter. C. AR-V7 ChIP analysis in 22Rv1 cells showing AR-FL knockdown diminishes AR-V7 binding to the PSA promoter. D. AR-FL ChIP analysis in 22Rv1 cells showing AR-V7 knockdown reduces AR-FL binding to the PSA promoter. The values of the IgG samples are set as 1, and the ChIP results are presented as relative fold of IgG. *, P < 0.05. Western blots showed the knockdown efficacy of AR-FL and AR-V7.