Table 2: Classification of a representative list of SLs-responsive genes (6 hrs) with at least 2 fold change.
| Function | ACCESSION | SYMBOL | DEFINITION | Fold-Change ST362 vs. control |
p-value | Fold-Change MEB55 vs. control |
p-value |
| Stress Response |
NM_002155.3 | HSPA6 | Homo sapiens heat shock 70kDa protein 6 (HSP70B') (HSPA6), mRNA. | 79.8 | 2.55E-05 | 158.7 | 1.09E-05 |
| NR_024151.1 | HSPA7 | Homo sapiens heat shock 70kDa protein 7 (HSP70B) (HSPA7), non-coding RNA. | 23.3 | 0.000290977 | 55.7 | 7.45E-05 | |
| NM_005346.3 | HSPA1B | Homo sapiens heat shock 70kDa protein 1B (HSPA1B), mRNA. | 9.2 | 2.21E-06 | 12.4 | 1.05E-06 | |
| NM_005345.4 | HSPA1A | Homo sapiens heat shock 70kDa protein 1A (HSPA1A), mRNA. | 7.3 | 6.92E-07 | 12.4 | 1.05E-06 | |
| NM_014365.2 | HSPB8 | Homo sapiens heat shock 22kDa protein 8 (HSPB8), mRNA. | 2.7 | 1.43E-05 | 3.6 | 3.18E-06 | |
| NM_005527.3 | HSPA1L | Homo sapiens heat shock 70kDa protein 1-like (HSPA1L), mRNA. | 2.7 | 0.00238603 | 3.9 | 0.00044493 | |
| NM_012111.1 | AHSA1 | Homo sapiens AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast | 2.1 | 0.0136702 | 2.6 | 0.0044504 | |
| Growth Factors |
NM_002632.4 | PGF | Homo sapiens placental growth factor (PGF), mRNA. | 6.2 | 0.0001284 | 7.0 | 8.86E-05 |
| Cytokines/ Signaling |
NM_004864.1 | GDF15 | Homo sapiens growth differentiation factor 15 (GDF15), mRNA. | 7.6 | 3.16E-05 | 19.0 | 3.66E-06 |
| NM_001001437.3 | CCL3L3 | Homo sapiens chemokine (C-C motif) ligand 3-like 3 (CCL3L3), mRNA. | 3.7 | 0.0371505 | |||
| NM_001024847.1 | TGFBR2 | Homo sapiens transforming growth factor, beta receptor II (70/80kDa) (TGFBR2), t | -2.0 | 0.0158406 | -2.3 | 0.00859784 | |
| Apoptosis | NM_004083.4 | DDIT3 | Homo sapiens DNA-damage-inducible transcript 3 (DDIT3), mRNA. | 6.2 | 0.000961245 | 14.1 | 0.000126234 |
| NM_004281.3 | BAG3 | Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA. | 4.6 | 3.87E-05 | 7.7 | 7.20E-06 | |
| NM_001165.3 | BIRC3 | Homo sapiens baculoviral IAP repeat-containing 3 (BIRC3), transcript variant 1, | -2.4 | 0.00864687 | -3.2 | 0.002218 | |
| Cellular adhesion |
NM_181702.1 | GEM | Homo sapiens GTP binding protein overexpressed in skeletal muscle (GEM), transcript. | 2.4 | 0.00147308 | 4.9 | 1.53E-05 |
| NM_012129.2 | CLDN12 | Homo sapiens claudin 12 (CLDN12), mRNA. | 2.3 | 0.00116056 | 2.5 | 0.000758471 | |
| Cell Cycle Regulation |
NM_004354.1 NM_031966.2 |
CCNG2 CCNB1 |
Homo sapiens cyclin G2 (CCNG2), mRNA. Homo sapiens cyclin B1 (CCNB1), mRNA |
3.6 -2.1 |
1.59E-05 0.00562257 |
3.1 | 3.16E-05 |
| Metabolism | NM_001013251.1 | SLC3A2 | Homo sapiens solute carrier family 3 (activators of dibasic and neutral amino ac | 3.6 | 0.00297397 | 3.4 | 0.00378565 |
| NM_020428.2 | SLC44A2 | Homo sapiens solute carrier family 44, member 2 (SLC44A2), mRNA. | 2.5 | 0.00318131 | 2.1 | 0.00883196 | |
| NM_001860.2 | SLC31A2 | Homo sapiens solute carrier family 31 (copper transporters), member 2 (SLC31A2), | 2.3 | 8.51E-05 | |||
| NM_014331.3 | SLC7A11 | Homo sapiens solute carrier family 7, (cationic amino acid transporter, y+ syste | 2.2 | 0.0388166 | 2.1 | 0.0461742 | |
| NM_000927.3 | ABCB1 | Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), mRN | 3.6 | 0.000245971 | 8.1 | 1.49E-05 | |
| NM_000963.1 | PTGS2 | Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase a | 3.4 | 0.0294943 | 6.9 | 0.00419823 | |
| NM_014330.2 | PPP1R15A | Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A | 2.7 | 0.000380118 | 3.7 | 7.56E-05 | |
| NM_000782.3 | CYP24A1 | Homo sapiens cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), n | -2.6 | 0.000579055 | -3.6 | 0.000113939 | |
| NM_000692.3 | ALDH1B1 | Homo sapiens aldehyde dehydrogenase 1 family, member B1 (ALDH1B1), nuclear gene | -2.1 | 0.00210428 | -3.1 | 0.00430455 | |
| Transcription | NM_001040619.1 | ATF3 | Homo sapiens activating transcription factor 3 (ATF3), transcript variant 4, mRN | 2.2 | 0.0184042 | 4.0 | 0.00147967 |
| NM_005938.2 | FOXO4 | Homo s apiens forkhead box O4 (FOXO4), mRNA. |
2.5 | 0.000437924 | 2.2 | 0.000948698 | |
| NM_004472.2 | FOXD1 | Homo sapiens forkhead box D1 (FOXD1), mRNA. | -2.4 | 0.0361717 | -2.7 | 0.0212245 |