Table 6.
Adjusted hazard ratios (HR) and 95 % confidence intervals (CI) for the GEHA Italian 90+ siblings stratified by Recruitment Centre (*n.s. = p > 0.05) estimated by multivariate Cox regression model
| Adjusted hazard ratios for age | Adjusted hazard ratios for age and recruitment centre | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bologna | Rome | Calabria | Total population | |||||||||||||
| Characteristic | HR | (95 % CI) | p | HR | (95 % CI) | p | HR | (95 % CI) | p | HR | (95 % CI) | p | ||||
| Gender | ||||||||||||||||
| Male | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
| Female | 0.801 | 0.439 | 1.462 | n.s.* | 0.584 | 0.408 | 0.835 | 0.003 | 0.837 | 0.603 | 1.161 | n.s.* | 0.735 | 0.589 | 0.916 | 0.006 |
| Five items ADL scale categories | ||||||||||||||||
| Severely disabled (ADL = 0–1–2) | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
| Moderately disabled (ADL = 3–4) | 0.981 | 0.504 | 1.909 | n.s.* | 0.689 | 0.397 | 1.197 | n.s.* | 0.649 | 0.341 | 1.235 | n.s.* | 0.736 | 0.541 | 1.003 | 0.052 |
| Not disabled (ADL = 5) | 0.704 | 0.390 | 1.271 | n.s.* | 0.622 | 0.381 | 1.016 | 0.058 | 0.752 | 0.584 | 0.967 | 0.026 | 0.677 | 0.547 | 0.836 | <0.001 |
| SMMSE categories | ||||||||||||||||
| Severe impairment: score 0–17 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
| Mild impairment: score 18–23 | 0.634 | 0.268 | 1.499 | n.s.* | 0.761 | 0.481 | 1.204 | n.s.* | 0.718 | 0.540 | 0.955 | 0.023 | 0.766 | 0.610 | 0.964 | 0.023 |
| Unimpairment: score 24–30 | 1.015 | 0.510 | 2.021 | n.s.* | 0.591 | 0.384 | 0.910 | 0.017 | 0.906 | 0.520 | 1.577 | n.s.* | 0.806 | 0.634 | 1.026 | n.s.* |
| Self-reported health | ||||||||||||||||
| Acceptable/poor/very poor | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
| Excellent/good | 0.641 | 0.398 | 1.033 | 0.068 | 0.789 | 0.549 | 1.134 | n.s.* | 0.834 | 0.623 | 1.116 | n.s.* | 0.818 | 0.673 | 0.995 | 0.045 |
| Anthropometric measures and physical test | ||||||||||||||||
| Body mass index (BMI, Kg/m2) | ||||||||||||||||
| <Median value | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
| ≥Median value | 0.608 | 0.369 | 1.002 | 0.051 | 0.660 | 0.470 | 0.928 | 0.017 | 0.926 | 0.738 | 1.162 | n.s.* | 0.781 | 0.656 | 0.929 | 0.005 |
| Hand grip (Kg) | ||||||||||||||||
| <Median value | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||||||
| ≥Median value | 1.329 | 0.740 | 2.387 | n.s.* | 0.740 | 0.512 | 1.069 | n.s.* | 0.739 | 0.560 | 0.975 | 0.033 | 0.809 | 0.664 | 0.985 | 0.035 |
| Haematochemical parameters | ||||||||||||||||
| Haemoglobin (g/dl) | 0.893 | 0.739 | 1.079 | n.s.* | 0.893 | 0.787 | 1.013 | n.s.* | 0.885 | 0.809 | 0.969 | 0.008 | 0.892 | 0.834 | 0.954 | 0.001 |
| Creatinine (mg/dl) | 1.078 | 0.695 | 1.672 | n.s.* | 1.737 | 1.034 | 2.919 | 0.037 | 1.278 | 0.902 | 1,811 | n.s.* | 1.387 | 1.082 | 1.777 | 0.010 |
| Total cholesterol (mg/dl) | 1.000 | 0.992 | 1.007 | n.s.* | 0.998 | 0.994 | 1.002 | n.s.* | 0.996 | 0.993 | 0.999 | 0.006 | 0.997 | 0.995 | 1.000 | 0.026 |