Fig. 4.

Relationship between age and anti-CMV CD8+ T cell responses in advanced aging. a Percentages and b absolute numbers of functional anti-CMV T cell responses are correlated with age. c Percentages and d absolute numbers of anti-pp65pentamer + T cells are correlated with age. Anti-pp65pentamer + T cells were separated to denote anti-pp65pentamer + CM and anti-pp65pentamer + EM T cells and percentages (e and f, respectively), or absolute numbers (g and h, respectively), are represented in correlation with age. All the correlations were assessed by Spearman’s rank test. The Spearman’s rank correlation coefficients (r _s) and the best fit are shown. Both the functional anti-CMV and anti-pp65pentamer + CD8+ T cell absolute numbers are shown in a log-scale. p values <0.05 were considered significant