Table 2.
IL-1 family cytokine and receptor levels in CSF and serum of sALS patients
| Cytokine/Receptor |
CSF |
Serum |
||
|---|---|---|---|---|
| ALS | Controls | ALS | Controls | |
|
IL-1β |
<7.8 |
<7.8 |
<7.8 (n = 1; 47.2) |
<7.8 (n = 1; 26.6) |
|
IL-1Ra |
<78.1 |
<78.1 (n = 1; 101.7) |
<78.1 (n = 1; 547.4) |
<78.1 |
|
sIL-1R2 |
<312.5 |
<312.5 (n = 1; 325.7) |
5673.4 ± 2771.5 |
5575.0 ± 1359.5 |
|
IL-33 |
<30.0 (n = 3; 72.9 ± 32.3) |
<30.0 (n = 3; 54.8 ± 27.1) |
625.4 ± 1570.5 |
536.3 ± 1166.3 |
|
sIL-1R4 |
<62.5 (n = 4; 85.1 ± 13.2) |
<62.5(n = 2; 85.5 ± 3.9) |
72.4 ± 16.4 |
79.9 ± 28.3 |
|
IL-37 |
<46.8 |
<46.8 |
<46.8 |
<46.8 (n = 1; 74.7) |
| IL-36 | NT | NT | 888.3 ± 729.3 | 1531.7 ± 1843.2 |
Values are given as mean pg/ml ± SD rather than in nM since the MW of the mature forms of the cytokines and of the natural soluble receptors are not yet precisely defined.
CSF, Cerebrospinal fluid; n, Number of samples above the detection limit; NT, Not tested; sALS, sporadic amyotrophic lateral sclerosis.