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. 2014 May 20;7:38. doi: 10.1186/1756-6606-7-38

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Copyright © 2014 Lu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A diagram shows the conversion of silent voltage-independent sodium channel into active one in the axon of a GABAergic neuron after AISS expression. A) illustrates the functional silence of voltage-independent sodium channels (gray) on the axon, whereas VGSCs (blue) are active for the generation of the evoked spikes. B) illustrates the active state of this voltage-independent sodium channels on the axon (red), which are responsible for generating the spikelets or early phase of full spikes in AISS. VGSCs (blue) are activated for late phase of full spikes in AISS.