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. 2014 May 20;7:38. doi: 10.1186/1756-6606-7-38

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Copyright © 2014 Lu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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AISS induction is not affected by membrane potential hyperpolarization. AISS is induced under the voltage-clamp with the different holding potentials from −65 mV to −95 mV (n = 9). A) illustrates AISS induction under different membrane holding potentials at −65 (top trace), −75 (the second trace), −85 (the third trace) and −95 mV (bottom trace) from a GABAergic neuron. Calibration bars are 200 pA and 10 seconds. B) shows the number of spikes needed for inducing AISS under the different membrane holding potentials of −65, −75, −85 and −95 mV, in which the values for −75, −85 and −95 mV are normalized by the value for −65 mV. C) shows the frequencies of AISS induced under membrane holding potentials at −65, −75, −85 and −95 mV, in which the values for −75, −85 and −95 mV are normalized by the value for −65 mV.