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. 2014 May 20;7:38. doi: 10.1186/1756-6606-7-38

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Copyright © 2014 Lu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ATX-II accelerates AISS induction at hippocampal GABAergic neurons. AISS is induced under the control and subsequent application of ATX-II (50 nM) after the first round of AISS disappears for 6 minutes, a time interval similar to Figure 1. A) illustrates AISS induction under the control (top trace) and in presence of ATX-II (bottom trace). Calibration bars are 20 mV and 10 seconds. B) shows dynamical changes in threshold potentials under the control (blue symbols) and in presence of ATX-II (red symbols). C) shows the number of spikes needed for AISS onset under the control (blue bar) and in presence of ATX-II (red bar; asterisk, p < 0.05, n = 8).