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. Author manuscript; available in PMC: 2014 May 30.
Published in final edited form as: Nat Rev Mol Cell Biol. 2012 May 23;13(6):355–369. doi: 10.1038/nrm3359

Figure 2. Ribosome-associated factors affect ribosome function.

Figure 2

a | In Drosophila melanogaster, Reaper protein associates with the 40S small ribosomal unit, disrupts the cap-scanning mechanism of translational initiation and promotes the translation of mRNAs containing internal ribosome entry site (IRES) elements that may be required for cell death. b | Ribosome-bound RACK1 can potentially localize ribosomes to the cell membrane by interacting with transmembrane receptors. RACK1 can recruit the microRNA (miRNA)-induced silencing complex (miRISC) to the ribosome to facilitate miRNA-mediated repression. RACK1 also binds to RNA-binding proteins such as yeast Scp160p, and this interaction may facilitate the recruitment of specific mRNAs to the ribosome.