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. 2013 Nov 19;9:708. doi: 10.1038/msb.2013.62

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Copyright © 2013, EMBO and Macmillan Publishers Limited

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/.

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Strain-specific differences in T. gondii metabolism. (A) Predicted strain-specific doubling times for four strains of T. gondii: Strains RH and GT are Type I parasites, and strains Me49 and Prugniaud are Type II parasites. (B) Breakdown of single knockout predictions is classified according to growth ratio with respect to wild type: essential, major effect, minor effect, and no effect. (C) Network visualization of predicted impact of reaction knockouts. In addition to identifying reaction knockouts that impact growth of Me49, enzyme reactions (diamond nodes) are colored according to their relative impact between strains Me49 and RH. (D) Essential enzymes (EC identifiers) predicted by iCS382 compared to Plasmodium falciparum model iCH579, and a gold standard of biochemically determined essential enzymes. Numbers in brackets show enzymes unique to that species.