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Four-compartment mamillary structural model. Comp1, central compartment; Comp2, peripheral blood mononuclear cell compartment; Comp3, polymorphonuclear cell compartment; and Comp4, tissue compartment. Azithromycin concentrations in whole blood are equal to A*[Comp1] + B*[Comp2] + C*[Comp3], where the coefficients A and B were estimated empirically, and C was fixed. CL12, 13, 14, and 41 are intercompartmental clearances; CL1–3 are elimination clearances.
