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. 2014 May 30;9(5):e97758. doi: 10.1371/journal.pone.0097758

Figure 6. A30P expression in dopaminergic neurons causes odor acuity and discrimination deficits in aged A30P flies.

Figure 6

Fifteen-days old A30P flies expressing A30P under Elav-gal4 (Elav), TH-gal4 (TH), Cha-gal4 (Cha) or Or83b-gal4 (Or83b) drivers were tested for odor acuity (A) and the performance of odor discrimination (B). Young wild-type flies of 1–2 days old were used as internal assay control. Only A30P expressed in dopamine neurons, A30PTH, showed olfactory acuity and discrimination deficits as seen in A30PElav. The corresponding controls for each comparison were CTElav (Elav/+; +/+; +/+), CTTH (+/+; +/+; TH/+), CTCha (+/+; +/+; Cha/+), and CTOr83b (Or83b/+; +/+; +/+). OA: tElav(14) = 6.388, ***P<0.0001, tTH(14) = 3.773, **P = 0.0021; OD: tElav(14) = 3.338, **P = 0.0049, tTH(14) = 3.257, **P = 0.0057; Student t-test.