Figure 4.

Few donor-derived cells express dopaminergic marker TH. (A–I): Some GFP-immunoreactive (GFP-ir) soma were also TH-immunoreactive (TH-ir) in areas where grafted cells overlapped with spared endogenous TH-ir dopamine cells in the substantia nigra but typically lacked significant arborization. (D–F) show higher magnifications of the box drawn in (C). (G–I) are from a different monkey than (A–F). Arrows point to GFP-ir donor-derived TH-ir cells. Arrowheads point to endogenous TH-ir cells, and asterisks demarcate donor-derived GFP-ir cells that are not TH-ir. Scale bars = 200 μm (C) applies to (A–C), and 50 μm (F, I) applies to (D–I). Abbreviations: GFP, green fluorescent protein; TH, tyrosine hydroxylase.