Table 3. DAVID functional annotation cluster analysis in the 2006 genes differentially expressed in cervical cancer.
| Cluster* | Regulation | Biological process | # Genes | p-value | FC |
| 1 | + | cell cycle | 207 | 1.20E-38 | 2.5 |
| + | mitosis (1) | 84 | 6.10E-27 | 3.6 | |
| 2 | + | DNA metabolic process | 122 | 8.40E-19 | 2.3 |
| + | DNA repair | 68 | 1.50E-10 | 2.3 | |
| 3 | + | chromosome segregation | 36 | 3.60E-14 | 4.2 |
| 4 | +/− | cytoskeleton organization | 83 | 1.20E-07 | 1.8 |
| 5 | − | developmental process | 428 | 7.50E-10 | 1.3 |
| − | cell differentiation | 209 | 1.80E-03 | 1.2 | |
| 6 | + | regulation of cell cycle | 76 | 8.90E-11 | 2.2 |
| + | cell cycle checkpoint | 29 | 1.10E-07 | 3 | |
| 7 | − | response to endogenous stimulus | 81 | 1.90E-08 | 1.9 |
| 8 | + | meiotic cell cycle | 31 | 7.10E-08 | 2.9 |
| 9 | + | DNA packaging | 44 | 4.60E-14 | 3.6 |
| + | chromosome organization | 97 | 6.30E-10 | 1.9 | |
| 10 | − | angiogenesis | 34 | 2.40E-05 | 2.2 |
| 12 | + | interphase | 28 | 1.00E-05 | 2.5 |
| 22 | − | cell migration (2) | 49 | 3.40E-04 | 1.7 |
| 23 | + | mitotic cell cycle spindle assembly checkpoint (3) | 6 | 3.50E-03 | 5.2 |
| + | negative regulation of mitotic metaphase/anaphase transition (3) | 6 | 3.50E-03 | 5.2 | |
| 24 | + | DNA strand elongation during DNA replication | 5 | 5.70E-04 | 9.5 |
| 25 | + | DNA replication initiation | 10 | 9.10E-06 | 5.9 |
| + | DNA geometric change (4) | 6 | 3.50E-02 | 3.2 | |
| 28 | + | double-strand break repair | 19 | 4.70E-05 | 2.9 |
| 29 | + | regulation of DNA metabolic process | 27 | 1.10E-04 | 2.2 |
| + | DNA replication checkpoint (6) | 4 | 3.00E-02 | 5.4 | |
| 33 | − | regulation of cell adhesion | 28 | 1.00E-03 | 1.9 |
| 36 | + | regulation of ubiquitin-protein ligase activity during mitotic cell cycle (5) | 16 | 6.50E-03 | 2.1 |
| + | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 14 | 1.70E-02 | 2 | |
| + | negative regulation of ubiquitin-protein ligase activity | 14 | 2.10E-02 | 2 | |
| 39 | − | epidermal cell differentiation | 15 | 1.70E-02 | 2 |
| 41 | + | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 201 | 1.10E-05 | 1.3 |
| 52 | NC | regulation of chemotaxis (7) | 8 | 3.90E-02 | 2.4 |
*The cluster number was obtained when the analysis was run with the whole gene set, including up- and down-regulated genes.
FC = Fold change is the ratio of the proportion of genes in the tested list versus the Human Gene Reference database.
NC = No clustered in up (+) and down (−) regulated genes analyzed separately.
The clusters in italics were enriched when the functional annotation cluster analysis was run at the highest stringency, and the number inside the parenthesis indicated the order the cluster occupied in the list.