Amitriptyline: (Elavil)
Standard dosage:	Start at 10-25 mg at bedtime; titrate to 100 mg (max 50 mg if taking an SSRI/SNRI)
Contraindications:	TCA allergies
Main drug interactions	MAOIs, St. John’s Wort, clonidine. Use with caution with other medications that cause QTc prolongation
Main side effects:	sedation, orthostatic hypotension, urinary retention, and dry mouth.
Special points:	Avoid in older adults.
Cost:	Low cost
Nortriptyline:(Pamelor)
Standard dosage:	Start at 10-25 mg, titrate to 100 mg (max 50 mg if taking an SSRI/SNRI)
Contraindications:	TCA allergies
Main drug interactions:	Alcohol can increase side effects. Use with caution with other medications that cause QTc prolongation.
Main side effects:	sedation, orthostatic hypotension, and dry mouth
Special points:	Try at least 2 TCAs but avoid in older adults (65+ years). It has less hypotension than Amitriptyline.
Cost:	Low cost