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. Author manuscript; available in PMC: 2015 Jun 10.
Published in final edited form as: Clin Chim Acta. 2014 Mar 22;433:157–168. doi: 10.1016/j.cca.2014.03.016

Fig. 2.

Fig. 2

Ion spectra of ritonavir generated by Exactive-MS (A) with the inclusion of an in-source collision-induced dissociation scan event for fragment production and detection (B) . Based on the m/z fragment ions monitored, we postulate that the m/z 268 and m/z 296 fragment ions were formed through the cleavage of a keto-isopropyl linkage and an amide bond, respectively. Retention time determination through the application of a mass filter with ± 5 ppm discrimination from theoretical mass of precursor and fragment ions (C).