Table 2.
Within-run precision of antiretroviral agent signal intensity and retention time.
| High ARV control mixture | Low ARV control mixture | High and Low ng/ml ARV control mixture | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Analyte | Mean Signal Intensity (NL) (n=5) | SD | %CV | Mean Signal Intensity (NL) (n=5) | SD | %CV | Retention Time (min) (n=10) | SD | %CV |
| Protease Inhibitors | |||||||||
| Amprenavir | 6124463 | 183537 | 3.0 | 542972 | 26390 | 4.9 | 7.67 | 5.3E-03 | 0.07 |
| Atazanavir | 45121330 | 1625272 | 3.6 | 4192407 | 125739 | 3.0 | 8.56 | 5.7E-03 | 0.07 |
| Darunavir | 596270 | 57653 | 9.7 | 55117 | 7994 | 14.5 | 7.67 | 5.3E-03 | 0.07 |
| Indinavir | 28150923 | 1947717 | 6.9 | 2541560 | 310821 | 12.2 | 9.16 | 9.3E-02 | 1.01 |
| Lopinavir | 4612419 | 347425 | 7.5 | 358328 | 36614 | 10.2 | 8.89 | 1.3E-02 | 0.14 |
| Nelfinavir | 24949052 | 3455300 | 13.8 | 1139909 | 129655 | 11.4 | 10.40 | 8.3E-02 | 0.80 |
| Ritonavir | 13136967 | 1013771 | 7.7 | 1330593 | 113751 | 8.5 | 8.73 | 2.1E-02 | 0.24 |
| Saquinavir | 11302342 | 1382993 | 12.2 | 414473 | 77056 | 18.6 | 10.74 | 8.1E-02 | 0.76 |
| Tipranavir | 2114155 | 123453 | 5.8 | 127775 | 28046 | 21.9 | 9.66 | 1.3E-02 | 0.13 |
| Nucleotide/Nucleoside Reverse Transcriptase Inhibitors | |||||||||
| Emtricitabine | 395381 | 11898 | 3.0 | 50474 | 1767 | 3.5 | 3.38 | 1.9E-02 | 0.57 |
| Lamivudine | 240402 | 10299 | 4.3 | 3020 | 291 | 9.6 | 1.98 | 2.3E-02 | 1.18 |
| Tenofovir | 27743 | 2107 | 7.6 | 1111 | 71 | 6.4 | 2.42 | 6.4E-02 | 2.64 |
| Zidovudine | 36033 | 4599 | 12.8 | 4055 | 1117 | 27.5 | 5.53 | 5.2E-03 | 0.09 |
| Non-nucleoside Reverse Transcriptase Inhibitors | |||||||||
| Efavirenz | 7274 | 1497 | 20.6 | 12422 | 1472 | 11.9 | 8.57 | 3.1E-02 | 0.37 |
| Nevirapine | 5964711 | 355374 | 6.0 | 1467214 | 69109 | 4.7 | 5.54 | 1.0E-02 | 0.19 |