Table 3.

Ontological clustering of predicted gene targets. The enrichment score, number of genes, and annotation is listed for the 3 most enriched clusters for each mirna listed indicating the most likely biological processes affected by these miRNAs after hypoxia.

miRNA	Cluster	Enrichment Score	# Gene Targets	Functional Annotation
miR-150	1	1.68	13	Protein homodimerization
	2	1.17	7	Negative regulator of DNA binding
	3	1.06	7	Vascular development
miR-24	1	1.34	15	Intracellular lumen
	2	1.18	3	Ligase activity
	3	1.08	5	Membrane associate
	4	0.9	4	Cell development and differentiation
miR-376-3p	1	1.56	9	Ubiquitin and catabolic related
	2	1.25	9	Mesoderm formation
	3	1.15	12	Neuron development
miR-140	1	1.93	8	Skeletal system, osteoblast
	2	1.51	26	Metal and ion/cation binding
	3	1.48	11	Protein localization and transport
miR-145	1	1.96	12	GTPase binding
	2	1.38	14	Embryonic development
	3	1.37	8	ER stress response
miR-345-5p	1	0.55	18	Membrane associated
	2	0.53	4	vesicles
	3	0.52	6	Protein transport
miR-126	1		1	p-55