Table 4.
Known genes regulating miRNAs or regulated by hypoxia sensitive miRNAs. genes that activate or inhibit transcription of listed miRNAs are shown in the first 2 columns. genes that are activated or inhibited by miRNAs are listed in the last 2 columns.
| miRNA | Influenced by | Effect | Target Gene | Effect |
|---|---|---|---|---|
| miR-24 | BMP2 | activation | KHSRP | activation |
| HIF1A | activation | FEN1 | inhibition | |
| p53 | activation | FOXP3 | inhibition | |
| HTLV1 | activation | Furin | inhibition | |
| TGF-β | activation | GATA-2 | inhibition | |
| AML-1 | activation | Histone H2 | inhibition | |
| E2F1 | activation | HNF4-α | inhibition | |
| E2F3 | activation | NET1 | inhibition | |
| ESR2 | activation | NIPK | inhibition | |
| RelA | activation | p120GAP | inhibition | |
| AML1 | inhibition | PAK4 | inhibition | |
| ESR1 | inhibition | STING | inhibition | |
| miR-126 | G-CSF | activation | VEGF-A | inhibition |
| TLR4 | activation | CYP2A13 | inhibition | |
| VEGF-A | activation | EGFL7 | inhibition | |
| ETS1 | activation | RGS16 | inhibition | |
| ETS2 | activation | SDF-1 | inhibition | |
| p53 | activation | SLC45A3 | inhibition | |
| FGF2 | inhibition | ADAM9 | inhibition | |
| IL-3 | inhibition | CRK | inhibition | |
| NGF | inhibition | DNMT1 | inhibition | |
| IBP2 | inhibition | |||
| IRS-1 | inhibition | |||
| K-RAS | inhibition | |||
| MER | inhibition | |||
| p85-β | inhibition | |||
| PITPNC1 | inhibition | |||
| PLK2 | inhibition | |||
| PTP-MEG2 | inhibition | |||
| SDF-1 | inhibition | |||
| SHMT2 | inhibition | |||
| SLC7A5 | inhibition | |||
| SOX2 | inhibition | |||
| TOM1 | inhibition | |||
| VCAM1 | inhibition | |||
| HOXA9 | inhibition | |||
| SPRED1 | inhibition | |||
| miR-140 | p53 | activation | SFD-1 | inhibition |
| SOX5 | activation | dynamin-1 | inhibition | |
| SOX6 | activation | GLUT3 | inhibition | |
| SOX9 | activation | RIP140 | inhibition | |
| IFN-γ | inhibition | situin1 | inhibition | |
| IL-1α | inhibition | aggrecanase-2 | inhibition | |
| IL-1β | inhibition | BMP2 | inhibition | |
| TNF-α | inhibition | dnpep | inhibition | |
| EGR2 | inhibition | |||
| HDAC4 | inhibition | |||
| IBP5 | inhibition | |||
| SMAD3 | inhibition | |||
| SP1 | inhibition | |||
| ULBP1 | inhibition | |||
| Mir-145 | BMP4 | activation | VEGF-A | inhibition |
| IFN-β | activation | N-cadherin | inhibition | |
| IFN-γ | activation | Oct-3/4 | inhibition | |
| MKL1 | activation | p70 S6 | inhibition | |
| TGF-β | activation | PAI1 | inhibition | |
| CSX | activation | Rhotekin | inhibition | |
| FKHR | activation | RLI | inhibition | |
| FOXO3A | activation | RREB1 | inhibition | |
| KLF2 | activation | situin1 | inhibition | |
| p53 | activation | SMAD3 | inhibition | |
| SMAD3 | activation | SOX2 | inhibition | |
| SMAD4 | activation | SOX9 | inhibition | |
| SRF | activation | SWAP-70 | inhibition | |
| NOTCH-1 | activation | PLK-1 | inhibition | |
| myocardin | activation | |||
| EGFR | inhibition | |||
| C/EBP-β | inhibition | |||
| EWS | inhibition | |||
| Oct-3/4 | inhibition | |||
| PRDM5 | inhibition | |||
| RREB1 | inhibition | |||
| miR-150 | c-MPL | activation | IL-10 | activation |
| IFN-α | activation | AKT2 | inhibition | |
| IFN-β | activation | c-Myb | inhibition | |
| SDF-1 | activation | CXCR4 | inhibition | |
| TLR3 | activation | NAP57 | inhibition | |
| FOXP1 | inhibition | |||
| Huntington | inhibition | |||
| IL-18 | inhibition | |||
| Mucin4 | inhibition | |||
| NOTCH3 | inhibition | |||
| P2X7 | inhibition | |||
| p53 | inhibition | |||
| PDGF-B | inhibition | |||
| Survivin | inhibition | |||
| Utrophin | inhibition | |||
| TNF-α | inhibition | |||
| miR-345 | none | ABCC1 | inhibition | |
| BAG-3 | inhibition | |||
| p21 | inhibition | |||
| miR-376b | MEF2 | activation | ATG4C | inhibition |
| NF-κB | inhibition | BDNF | inhibition | |
| Beclin1 | inhibition |