Table 1.
Genotype designations
a
|
PBP3 substitutions
b
|
||||
---|---|---|---|---|---|
SSN |
KTG |
||||
Category c | Level | Group | S385 | R517 | N526 |
rPBP3 |
High |
IIId |
T |
|
K |
|
|
III-likee |
T |
H |
|
|
Low |
II |
|
|
K |
|
|
I |
|
H |
|
sPBP3 | NA | NA |
aAccording to Ubukata et al.[7], Hasegawa et al.[8], Garcia-Cobos et al.[9], Hotomi et al.[10] and this study. NA, not applicable.
bEssential amino acid substitutions in PBP3 (transpeptidase domain, 338–573) with the amino acid sequence of H. influenzae Rd KW20 [GenBank:U32793] as reference. SSN, Ser-Ser-Asn motif; KTG, Lys-Thr-Gly motif.
crPBP3, isolates with PBP3 sequences conferring resistance to beta-lactams (isolates assigned to groups I, II, III-like and III); sPBP3, isolates with PBP3 sequences conferring wild-type susceptibility to beta-lactams (remaining isolates).
dOriginally reserved for isolates with the additional substitutions M377I and L389F by Ubukata et al.[7], modification proposed by Hotomi et al.[10].
eOriginally categorized as group I by Ubukata et al.[7], new group assignment proposed by Garcia-Cobos et al.[9].