. Author manuscript; available in PMC: 2015 Jun 1.

Published in final edited form as: Trends Genet. 2014 May 1;30(6):245–253. doi: 10.1016/j.tig.2014.03.005

Table 1.

RNA processing factors whose mutation elevates R-loops and genome instability phenotypes.

Genes	Organism
RNA Polymerase II transcription regulation and chromatin modification
BRE1 [68], CDC36 [30], LEO1 [38], MED12 [38], MED13 [11], MOT1 [30], RTT103 [18], SDS3 [30], SIN3 [11, 38], SPT2 [17], TAF5 [30]	S. cerevisiae
THO complex
HPR1 [69]^c [28]^bc [12]^b [32]^c, MFT1 [32]^c, THO2 [69]^a [28]^a, THP2 [70]^c	C. elegans^a Homo sapien^b S. cerevisiae^c
mRNA cleavage and polyadenylation, transcription termination
CLP1 [18]^c, CFT2 [18]^c, FIP1 [18]^c, PCF11 [18]^c, RNA14 [6]^c, RNA15 [18]^c, SEN1[71]^b [33]^c [22]^a	H. sapien^a Mus musculus^b S. cerevisiae^c
Splicing
ASF/SF2 [13]^b [5] ^ab, MUD2 [30]^c, NPL3⁷²^c, PRP31 [30]^c, SNU114 [30]^c, YHC1 [30]^c	Gallus gallus^a H. sapien^b S. cerevisiae^c
rRNA processing
DBP6 [30], DBP7 [30], IMP4 [30], RPF1 [30], SNU13 [30], SNU66 [30]	S. cerevisiae
Exosome and RNA degradation
DIS3 [30], KEM1/XRN1 [6, 38], RNH1 [11, 18, 30], RNH201 [6, 18], RRP6 [38], TRF4 [35]	S. cerevisiae
Nuclear export
CRM1 [6], MEX67 [4], MTR2 [4], MTR3 [6], NAB2 [73], NUP60 [6], NUP133 [30], RNA1 [30], SAC3 [73], SRM1 [18], STS1 [30], SUB2 [4, 14, 30], THP1 [73], YRA1 [4]	S. cerevisiae