Table 1.

Demographic and Clinical Characteristics of Patients With PHTSs With Primary Cancer and SMNs

Variable	PHTS With ≥ Two Cancers (n = 46)		PHTS With One Cancer (n = 68)		P
	No.	%	No.	%
Age at first cancer diagnosis, years					.66
Median	43.5		40.5
Range	7-66		9-69
Sex					.02
Male	4	9	19	28
Female	42	91	49	72
CC score					.39
Median	20.5		27
Range	4-55		1-69
First primary cancer
Breast	18	39	21	31	.42
Thyroid	10	22	23	34	.21
Endometrial	11	24	5	7	.03
Renal	2	4	6	9	.47
Other	5	11	13	19	.27

Abbreviations: CC, Cleveland Clinic; PHTS, PTEN hamartoma tumor syndrome; SMN, second malignant neoplasm.