Table 2.
Clinical Characteristics of Patients With PHTSs With SMNs
| Patient ID No. | Sex | CC Score | Age (years) |
Type of Cancer |
Interval From Primary Cancer to SMN (years) | PTEN Mutation | |||
|---|---|---|---|---|---|---|---|---|---|
| Study Enrollment | Primary Cancer Diagnosis | Primary | Second | Subsequent | |||||
| 5482 | F | 14 | 57 | 48 | Breast | Breast | Endometrial | 3 | c.277C>T p.(His93Tyr) |
| 5580 | F | 24 | 54 | 50 | Breast | Breast | Ovarian | 2 | c.388C>T p.(Arg130*) |
| 5355 | F | 13 | 57 | 39 | Breast | Breast | Thyroid | 10 | c.388C>T p.(Arg130*) |
| 9242 | F | 14 | 59 | 54 | Breast | Breast | Thyroid | < 1 | c.517C>T p.(Arg173Cys) |
| 1432 | F | 16 | 42 | 44 | Breast | Breast | < 1 | c.388C>G p.(Arg130Gly) | |
| 2844 | F | 28 | 60 | 54 | Breast | Breast | 6 | c.209 + 1G>T | |
| 5822 | F | 17 | 56 | 32 | Breast | Breast | 13 | c.80-?_164+?del | |
| 7274 | F | 18 | 72 | 48 | Breast | Breast | 23 | c.389G>A p.(Arg130Gln) | |
| 8171 | F | 14 | 59 | 50 | Breast | Breast | 8 | c.238A>T p.(Lys80Ter) | |
| 9358 | F | 15 | 61 | 61 | Breast | Breast | 1 | c.696dupA p.(Thr233fs) | |
| 1216 | F | 37 | 39 | 29 | Breast | Ovarian | 17 | c.389G>A p.(Arg130Gln) | |
| 7155 | F | 31 | 64 | 46 | Breast | Endometrial | Renal, breast | 3 | c.70G>C p.(Asp24His) |
| 590 | F | 15 | 51 | 51 | Breast | Endometrial | < 1 | c.388C>T p.(Arg130*) | |
| 3910 | F | 17 | 57 | 36 | Breast | Endometrial | 5 | c.1033C>G p.(Leu345Val) | |
| 7082 | F | 22 | 56 | 49 | Breast | Endometrial | 7 | c.71A>G p.(Asp24Gly) | |
| 9513 | F | 14 | 70 | 65 | Breast | Endometrial | 3 | c.46T>C p.(Tyr16His) | |
| 5928 | F | 42 | 49 | 43 | Breast | Small intestine | 6 | c.210-4_210-1delTTAG | |
| 6243 | F | 4 | 57 | 50 | Breast | Thyroid | 5 | -834C>T | |
| 3944 | F | 14 | 49 | 47 | Colorectal | Breast | 2 | c.182A>G p.(His61Arg) | |
| 5151 | F | 46 | 54 | 35 | Colorectal | Endometrial | Breast | 18 | c.697C>T p.(Arg233*) |
| 7112 | F | 41 | 51 | 47 | Endometrial | Breast | 1 | c.883_884insT p.(Cys296Metfs*2) | |
| 8008 | F | 29 | 51 | 49 | Endometrial | Breast | < 1 | c.323T>C p.(Leu108Pro) | |
| 8370 | F | 16 | 58 | 47 | Endometrial | Breast | 11 | c.672dupA p.(Tyr225fs) | |
| 10402 | F | 66 | 66 | 31 | Endometrial | Breast | 35 | c.160_162del3 | |
| 3015 | F | 16 | 47 | 43 | Endometrial | Colorectal | 4 | c.720C>A p.(Tyr240*) | |
| 5760 | F | 45 | 49 | 34 | Endometrial | Melanoma | Thyroid | 7 | c.72_73insAGA p.(Asp24_Leu25insArg) |
| 7851 | F | 32 | 38 | 30 | Endometrial | Renal | Breast | 2 | c.388C>T p.(Arg130*) |
| 10071 | F | 22 | 59 | 46 | Endometrial | Renal | Ovarian | 8 | c.79T>A p.(Tyr27Asn) |
| 1186 | F | 25 | 43 | 34 | Endometrial | Renal | 16 | c.1027-2A>C | |
| 1716 | F | 38 | 61 | 61 | Endometrial | Renal | < 1 | c.388C>T p.(Arg130*) | |
| 5191 | F | 46 | 41 | 38 | Endometrial | Thyroid | 3 | c.734_737del4 p.(Gln245Argfs*10) | |
| 7764 | F | 31 | 50 | 32 | Melanoma | Endometrial | Breast | 17 | c.491delA p.(Lys164Argfs*3) |
| 342 | M | 55 | 51 | 26 | Melanoma | Renal | 25 | c.388C>T p.(Arg130*) | |
| 8743 | M | 43 | 54 | 49 | Renal | Colorectal | 4 | c.164 + 1G>T | |
| 1365 | F | 19 | 50 | 45 | Renal | Melanoma | 11 | c.1003C>T p.(Arg335*) | |
| 10077 | F | 10 | 40 | 21 | Thyroid | Bladder | 20 | c.389G>T p.(Arg130Leu) | |
| 1343 | F | 10 | 59 | 46 | Thyroid | Breast | 11 | c.203A>G p.(Tyr68Cys) | |
| 4566 | F | 19 | 41 | 35 | Thyroid | Breast | 3 | c.324delT p.(Asp109Thrfs*4) | |
| 6797 | F | 18 | 45 | 42 | Thyroid | Breast | 2 | c.697C>T p.(Arg233*) | |
| 1554 | M | 18 | 73 | 41 | Thyroid | Colorectal | 5 | c.633C>A p.(Cys211*) | |
| 435 | F | 19 | 52 | 33 | Thyroid | Endometrial | Breast | 13 | c.406T>C p.(Cys136Arg) |
| 7292 | F | 45 | 21 | 17 | Thyroid | Endometrial | Ovarian | 4 | c.509G>T p.(Ser170Ile) |
| 1084 | F | 16 | 26 | 26 | Thyroid | Ovarian | < 1 | c.655C>T p.(Q219*) | |
| 1352 | M | 23 | 26 | 7 | Thyroid | Renal | 14 | c.491delA p.(Lys164Argfs*3) | |
| 5350 | F | 17 | 44 | 36 | Thyroid | Renal | 8 | c.1003C>T p.(Arg335*) | |
| 1688 | F | 27 | 39 | 19 | Hodgkin lymphoma | Breast | 11 | c.1003C>T p.(Arg335*) | |
Abbreviations: CC, Cleveland Clinic; PHTS, PTEN hamartoma tumor syndrome; SMN, second malignant neoplasm.