Table 4.

Screening Recommendations for Patients With PHTSs

Cancer	General Population Risk (%)	Lifetime Risk With PHTSs (%)	Average Age at Diagnosis (years)	Screening
Breast	12	Approximately 85	40-49	Starting at age 30 years: annual mammogram; consider MRI for patients with dense breasts
Thyroid	1	35	30-49	Annual ultrasound
Endometrial	2.6	28	40-59	Starting at age 30 years: annual endometrial biopsy or transvaginal ultrasound
Renal cell	1.6	34	50-59	Starting at age 40 years: renal imaging every 2 years
Colon	5	9	40-49	Starting at age 35 years: colonoscopy every 2 years
Melanoma	2	6	40-49	Annual dermatologic examination

Abbreviations: MRI, magnetic resonance imaging; PHTS, PTEN hamartoma tumor syndrome.