Table 5.

Summary of evaluations of alternative cross-linking orientation biases

Orientation restriction
	Dynein	P	P	P	P	I	I	I	I	P	P	P	P	I	I	I	I
	HSET	P	P	P	P	P	P	P	P	I	I	I	I	I	I	I	I
	MEB	P	P	I	I	P	P	I	I	P	P	I	I	P	P	I	I
	Eg5	P	I	P	I	P	I	P	I	P	I	P	I	P	I	P	I
	dhme	-	-	-	+	-	+	+	+	-	+	+	+	+	+	+	+
Simulation cases	dhm	+	+	+	+	+	+	-	-	-	-	-	-	-	-	-	-
	dm	-	-	+	+	-	-	+	+	-	-	+	+	-	-	+	+
	hm	-	-	+	+	-	-	+	+	-	-	+	+	-	-	+	+
	dh	+	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-

D, dynein; E, Eg5; H, HSET; I, indiscriminate; M, minus-end cross-linking; P, parallel.

+, simulation outcome is not significantly different from combinatorial immunodepletion result (p > 0.05).

-, simulation outcome is significantly different from combinatorial immunodepletion result (p < 0.05).