Fig. 2.

Cortical activation during the social cognition (ToM) task assessed with the ‘Eyes’ test. Paired t-test computed for the LPS_ToM>gender > placebo_ToM>gender condition. LPS-treated subjects displayed a stronger activation in (A) superior temporal gyrus [(60, −6, 2), t = 5.18], (B) temporo-parietal junction [(54, −44, 22), t = 5.26], (C) fusiform gyrus [(−34, −24, −26), t = 5.47] and (D) precuneus [(44, −80, 34), t = 6.57] after administration of 0.4 ng/kg E. coli endotoxin (n = 18). All data based on ROI analysis using SVC with FWE correction. The images are presented using a threshold at P < 0.01 uncorrected for visualization purposes.