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. 2014 May 11;11:22. doi: 10.1186/1743-8977-11-22

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Copyright © 2014 Luanpitpong et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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p53 regulates CSC-like cells from SWCNT-exposed lung epithelial cells. (A) Western blot analysis of p53 protein (left) and tumor growth kinetics (right) of wild-type (WT) and p53-overexpressed BSW tumors. (B) Quantitative analysis of tumor spheres (left) and side population (right) in WT and p53-overexpressed BSW cells. (C) Cell invasion (left) and migration (right) assays of WT and p53-overexpressed BSW cells. Plots are relative invasion and migration level normalized to WT cells. (D) Analysis of stem cell surface markers CD24 and CD133 in WT and p53-overexpressed BSW cells using flow cytometry. Plots are relative fluorescence level normalized to WT cells. Data are means ± SD (n = 3). *p < 0.05 vs. WT cells. NS, not significant vs. BC cells.