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Schematic diagram representing the overall effects of SWCNT on tumorigenesis. (Left) Extrapolation of CNT dose in mouse and cell culture models to human exposure scenarios in the workplace. (Right) Lung biopersistence of SWCNT leads to their chronic interaction with lung epithelial cells and subsequent induction of CSC-like cells. Functional assays showing aggressive cancer phenotypes and tumorigenicity of CSC-like cells.
