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. 2014 Feb 25;13(3):529–539. doi: 10.1111/acel.12203

Figure 2.

Figure 2

Echocardiography. (A) Left ventricular mass index (LVMI) is significantly higher in old hearts at baseline (25 months old), when compared to young hearts (3 months old), indicating age-dependent left ventricular hypertrophy. After 10 weeks of CR or RP in old mice, LVMI is significantly lower than old control mice (P < 0.001 and P = 0.004, respectively). It is also significantly reversed when compared with the baseline echocardiography of each mouse (P < 0.01 for both CR and RP), indicating reversal of age-dependent ventricular hypertrophy. (B) Fractional shortening does not significantly change with age or treatment group. (C). Myocardial performance index (MPI) significantly worsened (increased) in old mice at baseline. CR or RP significantly improved the MPI in old hearts when compared with control mice. (P = 0.02 and 0.05, respectively). (D) Diastolic function measured by tissue Doppler imaging Ea/Aa significantly declined in old hearts. While old CL mice have progressive decline of Ea/Aa after 10 weeks, treatment with CR or RP significantly increased Ea/Aa. CL: ad libitum control diet, and CR: caloric restriction. *P < 0.05 vs. YCL; #P < 0.05 versus pretreatment. n = 5–8.