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. 2014 May 28;14:91. doi: 10.1186/1471-2466-14-91

Figure 4.

Figure 4

Comparison of fibroelastosis between the upper and lower lobes in a patient with idiopathic pleuroparenchymal fibroelastosis (IPPFE). High-resolution computed tomography (HRCT) of the right upper lobe shows pleural thickening and subpleural consolidation opacities (A). A lung section stained with hematoxylin and eosin (HE) shows subpleural fibrosis with an abrupt transition to normal lung parenchyma, similar to usual interstitial pneumonia (UIP) (B, ×12.5). A lung specimen stained with Elastica van Gieson (EVG) demonstrates deposition of dense elastic fibers (elastosis) in a subpleural fibrotic lung lesion (C, ×12.5). HRCT of the right lower lobe shows pleural thickening and consolidation opacities along a bronchovascular bundle with traction brochioloectasis (D). An HE-stained lung section from the right lower lobe shows a UIP-like lesion (E, ×12.5), and a EVG-stained specimen shows fewer elastic fibers in the right lower lobe (F, ×12.5) than in the right upper lobe (C) in the same patient. In this patient, the elastic fiber score in the lower lobe was 20.3%, whilst that in the upper lobe was 32.4%.