Table 2.
Comparison between idiopathic pleuroparenchymal fibroelastosis (IPPFE) and idiopathic pulmonary fibrosis (IPF): laboratory, physiologic, and bronchoalveolar lavage data
| IPPFE (n = 6) | IPF (n = 28) | p value | |
|---|---|---|---|
| Laboratory findings |
|
|
|
| Serum LDH, U/L |
192 ± 37 |
223 ± 43 |
0.106 |
| Serum KL-6, U/ml |
755 ± 473 |
1282 ± 888 |
0.199 |
| Serum SP-D, ng/ml |
298 ± 346 |
222 ± 136 |
0.527 |
| SP-D/KL-6 |
0.38 ± 0.20 |
0.26 ± 0.18 |
0.168 |
| Physiologic |
|
|
|
| Resting PaO2, mm Hg |
77.6 ± 11.5 |
83.2 ± 11.0 |
0.363 |
| Resting PaCO2, mm Hg |
43.5 ± 7.2 |
40.6 ± 3.1 |
0.138 |
| FVC, L |
1.97 ± 0.42 |
2.91 ± 0.91 |
0.021 |
| FVC, % predicted |
62.7 ± 10.9 |
88.6 ± 21.9 |
0.009 |
| DLCO, % predicted |
77.9 ± 13.4 |
89.0 ± 26.1 |
0.395 |
| ΔFVC in 12 mo, L |
-0.51 ± 0.35 |
-0.32 ± 0.38 |
0.364 |
| BAL fluid cell analysis |
|
|
|
| Lymphocytes, % |
6.0 ± 4.5 |
5.2 ± 7.0 |
0.782 |
| Neutrophils, % |
2.5 ± 3.3 |
0.6 ± 0.8 |
0.018 |
| Eosinophils, % | 1.7 ± 2.0 | 0.4 ± 0.6 | 0.011 |
Data are presented as mean ± SD.
Data are analysed with Student’s t-test.
Definition of abbreviations: FVC forced vital capacity, FEV1 forced expiratory volume in 1 second, DLCO diffusion lung capacity for carbon monoxide, BAL bronchoalveolar lavage.