Table 3.
Comparison between idiopathic pleuroparenchymal fibroelastosis (IPPFE) and idiopathic pulmonary fibrosis (IPF): findings on high resolution computed tomography (HRCT) and lung specimens
| IPPFE (n = 6) | IPF (n = 28) | p value | |
|---|---|---|---|
| Findings on HRCT |
|
|
|
| Extent score, 0-25 |
9.8 ± 2.6 |
8.8 ± 3.7 |
0.366 |
| Upper lobe predominant distribution, n (%) |
6 (100) |
0 (0) |
<0.0001* |
| Reticulation score, 0-3 |
1.3 ± 0.5 |
1.8 ± 0.7 |
0.161 |
| Glass score, 0-3 |
1.5 ± 0.8 |
1.7 ± 0.7 |
0.429 |
| Consolidation score, 0-3 |
1.7 ± 0.8 |
0.3 ± 0.5 |
0.004 |
| Existence of honeycombing, n (%) |
0 (0) |
10 (35.7) |
0.148* |
| Emphysema score, 0-3 |
0 |
0.7 ± 0.9 |
0.078 |
| Pleural thickening, n (%) |
6 (100) |
2 (7.1) |
<0.0001* |
| Findings on surgical lung biopsy specimens |
|
|
|
| Collagen deposition score, 0-3 |
2.0 ± 0 |
2.4 ± 0.8 |
0.175 |
| Existence of microscopic honeycombing, n (%) |
1 (16.7) |
17 (60.7) |
0.078* |
| Organizing pneumonia score, 0-3 |
1.8 ± 0.4 |
0.6 ± 0.7 |
0.003 |
| Cellularity score in interstitium, 0-3 |
1.5 ± 0.5 |
1.3 ± 0.6 |
0.456 |
| Lymphoid hyperplasia, n (%) |
0 (0) |
0 (0) |
NA. |
| Pleural fibrosis, pleuritis, n (%) | 5 (83.3) | 0 (0) | <0.0001* |
Data are presented as mean ± SD or, n (%).
Data are analysed with Mann-Whitney’s U-test or *Fisher’s exact probability test.
HRCT high resolution computed tomography, NA not applicable.