Table 1.
Compendium of AF genetic variants identified in families and individuals.
| Gene | Gene Name | Function | Citation(s) |
|---|---|---|---|
| ABCC9 | ATP-binding cassette, subfamily C, member 9 |
IKATP current | 129 |
| GATA4 | Transcription factor GATA-4 | Cardiac development | 45–47,130 |
| GATA5 | Transcription factor GATA-5 | Cardiac development | 48,49,131 |
| GATA6 | Transcription factor GATA-6 | Cardiac development | 50,132,133 |
| GJA5 | Connexin 40 | Formation of atrial gap junctions | 38,134–138 |
| GREM2 | Gremlin-2 | BMP antagonist | 139 |
| HCN4 | Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 |
If current | 103 |
| JPH2 | Junctophilin-2 | Ca2+ homeostasis | 140 |
| KCNA5 | Potassium voltage-gated channel, shaker-related subfamily, member 5 |
IKur current | 15,24–26 |
| KCND3 | Potassium voltage-gated channel, Shal- related subfamily, member 3 |
Ito1 current | 16 |
| KCNE1 | Potassium voltage-gated channel, Isk- related family, member 1 |
Kv channel activity modulation | 19 |
| KCNE2 | Potassium voltage-gated channel, Isk- related family, member 2 |
Kv channel activity modulation | 20 |
| KCNE3 | Potassium voltage-gated channel, Isk- related family, member 3 |
Kv channel activity modulation | 21 |
| KCNE5 | KCNE1-like | Kv channel activity modulation | 22 |
| KCNH2 | Potassium voltage-gated channel, subfamily H (eag-related), member 2 |
IKr current | 141,142 |
| KCNJ2 | Potassium inwardly-rectifying channel, subfamily J, member 2 |
IK1 current | 17,18 |
| KCNJ5 | Potassium inwardly-rectifying channel, subfamily J, member 5 |
IKACh current | 143 |
| KCNJ8 | Potassium inwardly-rectifying channel, subfamily J, member 8 |
IKATP current | 144 |
| KCNQ1 | Potassium voltage-gated channel, KQT- like subfamily, member 1 |
IKs current | 8 – 14 |
| LMNA | Lamin A/B | Nuclear envelope structure | 145,146 |
| NKX2.5 | Homeobox protein Nkx2.5 | Cardiac development | 43 |
| NPPA | Natriuretic Peptide Precursor A | Systemic sodium homeostasis | 39,147 |
| NUP155 | Nucleoporin 155 | Nuclear pore formation | 148 |
| PITX2c | Paired-like homeodomain 2c | Great vein development, left-right asymmetry |
44 |
| RYR2 | Ryanodine Receptor 2 | Ca2+ release from sarcoplasmic reticulum |
149 |
| SCN1B | Sodium channel, voltage-gated, type I, beta subunit |
INa current modulation | 34,37 |
| SCN2B | Sodium channel, voltage-gated, type II, beta subunit |
INa current modulation | 37 |
| SCN3B | Sodium channel, voltage-gated, type III, beta subunit |
INa current modulation | 35,36 |
| SCN4B | Sodium channel, voltage-gated, type IV, beta subunit |
INa current modulation | 33 |
| SCN5A | Sodium channel, voltage-gated, type V, alpha subunit |
INa current | 27 – 32 |