Table 1.
Gene | Gene Name | Function | Citation(s) |
---|---|---|---|
ABCC9 | ATP-binding cassette, subfamily C, member 9 |
IKATP current | 129 |
GATA4 | Transcription factor GATA-4 | Cardiac development | 45–47,130 |
GATA5 | Transcription factor GATA-5 | Cardiac development | 48,49,131 |
GATA6 | Transcription factor GATA-6 | Cardiac development | 50,132,133 |
GJA5 | Connexin 40 | Formation of atrial gap junctions | 38,134–138 |
GREM2 | Gremlin-2 | BMP antagonist | 139 |
HCN4 | Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 |
If current | 103 |
JPH2 | Junctophilin-2 | Ca2+ homeostasis | 140 |
KCNA5 | Potassium voltage-gated channel, shaker-related subfamily, member 5 |
IKur current | 15,24–26 |
KCND3 | Potassium voltage-gated channel, Shal- related subfamily, member 3 |
Ito1 current | 16 |
KCNE1 | Potassium voltage-gated channel, Isk- related family, member 1 |
Kv channel activity modulation | 19 |
KCNE2 | Potassium voltage-gated channel, Isk- related family, member 2 |
Kv channel activity modulation | 20 |
KCNE3 | Potassium voltage-gated channel, Isk- related family, member 3 |
Kv channel activity modulation | 21 |
KCNE5 | KCNE1-like | Kv channel activity modulation | 22 |
KCNH2 | Potassium voltage-gated channel, subfamily H (eag-related), member 2 |
IKr current | 141,142 |
KCNJ2 | Potassium inwardly-rectifying channel, subfamily J, member 2 |
IK1 current | 17,18 |
KCNJ5 | Potassium inwardly-rectifying channel, subfamily J, member 5 |
IKACh current | 143 |
KCNJ8 | Potassium inwardly-rectifying channel, subfamily J, member 8 |
IKATP current | 144 |
KCNQ1 | Potassium voltage-gated channel, KQT- like subfamily, member 1 |
IKs current | 8 – 14 |
LMNA | Lamin A/B | Nuclear envelope structure | 145,146 |
NKX2.5 | Homeobox protein Nkx2.5 | Cardiac development | 43 |
NPPA | Natriuretic Peptide Precursor A | Systemic sodium homeostasis | 39,147 |
NUP155 | Nucleoporin 155 | Nuclear pore formation | 148 |
PITX2c | Paired-like homeodomain 2c | Great vein development, left-right asymmetry |
44 |
RYR2 | Ryanodine Receptor 2 | Ca2+ release from sarcoplasmic reticulum |
149 |
SCN1B | Sodium channel, voltage-gated, type I, beta subunit |
INa current modulation | 34,37 |
SCN2B | Sodium channel, voltage-gated, type II, beta subunit |
INa current modulation | 37 |
SCN3B | Sodium channel, voltage-gated, type III, beta subunit |
INa current modulation | 35,36 |
SCN4B | Sodium channel, voltage-gated, type IV, beta subunit |
INa current modulation | 33 |
SCN5A | Sodium channel, voltage-gated, type V, alpha subunit |
INa current | 27 – 32 |