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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Neurovirol. 2014 Feb 19;20(3):309–313. doi: 10.1007/s13365-014-0237-7

Fig. 4. Expression of programmed death receptor (PD)-1 in blood of SVV-infected animals before immunosuppression and during reactivation (zoster).

Fig. 4

As described in Materials and methods, PD-1 expression was determined by flow cytometry in both CD4 (a and c) and CD8 (b and d) T cells before immunosuppression (142 dpi) and 48 days later (190 dpi) when 2 monkeys developed zoster. PD-1 expression increased significantly in CD4 and CD8 naive T cell subsets at the time of zoster in immunosuppressed monkeys (p=0.04 and 0.008, respectively). In the non-immunosuppressed monkey that developed zoster after the stress of isolation and transportation (c and d), PD-1 expression increased in CD4 memory and effector cells (b) but not in other cell types (d). Data points represent the mean value +/− SEM.