Table 11.
Main effect and interaction estimates for models with no three-way or four-way interactions.
| Domain (Gene) | Interaction | Time estimate* | Interaction estimate** | Standard Error | p-value |
|---|---|---|---|---|---|
| Motor (DRD3) | Time | 0.7441 | |||
| Motor | Time × DRD3 | −0.1106 | 0.04146 | 0.0077 | |
| Motor | Time × Stimulant | −0.2549 | 0.09969 | 0.0106 | |
| Motor | Time × HIV+ | 0.2175 | 0.06197 | 0.0005 | |
|
| |||||
| Speed† (BDNF) | Time | −0.02840 | |||
| Speed | Time × HIV+ | 0.3205 | 0.06075 | <.0001 | |
|
| |||||
| Motor (BDNF) | Time | 0.7181 | |||
| Motor | Time × BDNF | −0.1322 | 0.05997 | 0.0275 | |
| Motor | Time × Stimulant | −0.2646 | 0.09934 | 0.0077 | |
| Motor | Time × HIV+ | 0.2080 | 0.06130 | 0.0007 | |
|
| |||||
| Speed (MBL-2) | Time | 0.01543 | |||
| Speed | Time × HIV+ | 0.3590 | 0.07094 | <.0001 | |
|
| |||||
| Motor (MBL-2) | Time | 0.7425 | |||
| Motor | Time × Stimulant | −0.3528 | 0.1189 | 0.0030 | |
| Motor | Time × HIV+ | 0.2781 | 0.07062 | <.0001 | |
|
| |||||
| Working Memory (DBH) | Time | 0.3002 | |||
| Working Memory | Time × Stimulant | 0.4535 | 0.1458 | 0.0019 | |
|
| |||||
| Speed (ANKK1) | Time | −0.06188 | |||
| Speed | Time × HIV+ | 0.3116 | 0.05994 | <.0001 | |
|
| |||||
| Motor (ANKK1) | Time | 0.6667 | |||
| Motor | Time × Stimulant | −0.2620 | 0.09921 | 0.0083 | |
| Motor | Time × HIV+ | 0.2250 | 0.06092 | 0.0002 | |
|
| |||||
| Speed (CCL2) | Time | −0.03545 | |||
| Speed | Time × HIV+ | 0.3215 | 0.06040 | <.0001 | |
|
| |||||
| Speed (TNF-α) | Time | −0.1018 | |||
| Speed | Time × HIV+ | 0.3108 | 0.05994 | <.0001 | |
|
| |||||
| Motor (TNF-α) | Time | 0.6896 | |||
| Motor | Time × Stimulant | −0.2651 | 0.09920 | 0.0075 | |
| Motor | Time × HIV+ | 0.2223 | 0.06095 | 0.0003 | |
|
| |||||
| Speed (CCL3) | Time | −0.1197 | |||
| Speed | Time × HIV+ | 0.3166 | 0.06045 | <.0001 | |
|
| |||||
| Motor (CCL3) | Time | 0.7116 | |||
| Motor | Time × Stimulant | −0.2751 | 0.09945 | 0.0057 | |
| Motor | Time × HIV+ | 0.2165 | 0.06114 | 0.0004 | |
*
Time estimate indicates T-score change per year
**
Negative interaction estimates indicate greater decline relative to the overall estimate. Positive estimates indicate relative improvement.
†
Speed = Information Processing Speed