Figure 3.

Daily movement of melanosomes within the RPE. 57BL/6J mice were sacrificed just before light onset (A), 1.25 h (B), 2 h (C), 3.5 h (D), and 5.5 h (E) after light onset, and longitudinal sections of RPE were examined by transmission EM. Just before light onset not many melanosomes have entered the apical processes and those that have are in the base of the process. After 1.25 h phagosomes (arrows) are visible in the apical cytoplasm, but few melanosomes are in the apical processes. After 2 h more melanosomes are in the apical processes and some have penetrated into the region between the ROS. Bar, 2 μm.