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A comparison between the deoxy (A) and oxy (B) Hc from L. polyphemus show a large geometric change at the active site upon oxygen binding (the Cu-Cu distance shortens by 1.0 Å). While the overall topology of the active site in Hc is conserved, differences between oxy-Hc from the arthropod L. polyphemus (B) and the mollusc E. dofleini (C) can be observed especially at the CuA site. (PDB 1LLA (A), 1NOL (B), and 1JS8 (C))
